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Director, Translational Research

Company: Iovance Biotherapeutics, Inc.
Location: Tampa
Posted on: September 15, 2019

Job Description:

The Director, Translational Research will be responsible for managing a group of Scientists/Senior Research Associates. S(he) is responsible for developing novel approaches to optimize the anti-tumor activity of tumor infiltrating lymphocytes (TIL) for therapeutic applications and overseeing the clinical biomarker program. Research projects may include developing new processes for the expansion of new histologies’ T cells and modulating T cell metabolism to improve TIL potency. Translational activities will include implementing and ensuring the execution of assays aiming at monitoring the TIL mechanism of action. Analysis of clinical samples will be expected to reveal relevant predictive and pharmacodynamic biomarkers. Specific Responsibilities Supervise all correlative studies conducted internally and externally on Iovance’s clinical samples to identify biomarkers of TIL anti-tumor activity. Design and execute/oversee the execution of the laboratory experiments involved in assigned projects. Document, interpret, and troubleshoot all experiments with upmost scientific rigor. Generate thorough protocols/reports upon project completion and interim data packages as needed. Comply to QC and QA requirements for data management. Establish Master Service Agreements for sample analyses with outside providers and manage the collaborations. Lead multi-functional Translational Research team meetings. Support Regulatory and Clinical biomarker-related activities. Propose and develop innovative methods and technologies as well as new directions for project development. Identify patentable inventions and support their filings. Actively participate in internal and external scientific discussions. Follow latest advancements in the field by means of thorough and regular survey of relevant literature and scientific conference attendance. Manage and lead at least a couple of direct reports. Education and Qualifications PhD in Cellular Biology, Molecular Biology, Immunology, or related discipline required. Three years or more of post-doctoral training in academia or industry research laboratory. Twelve+ years’ experience after completion of post-doc; industry setting preferred. In-depth knowledge of cancer biology and immuno-oncology, as well as familiarity with current immunotherapeutic approaches and related biomarker programs. Extensive technical expertise in the fields of tissue culture using primary and established cell lines,  in vitro  T cell functional assays, flow cytometry staining and acquisition techniques, molecular biology, and state-of-the-art gene expression profiling; experience with deep sequencing, viral vectors, and stem cells a plus. Fluency with major scientific software and online resources; familiarity with complex data analysis methods/software packages helpful. Quality peer-reviewed publication record in relevant fields. Exceptional work ethic. Excellent communication skills in person and over conference calls with a variety of individuals from internal research staff to academic collaborators, business partners, lawyers, and executive team. Highly motivated individual, who adapts to new situations and wants to be part of a dynamic and growing team; must have collaborative spirit. LOCATION: Tampa, FL or San Carlos, CA; Prefer Tampa, FL

Keywords: Iovance Biotherapeutics, Inc., Tampa , Director, Translational Research, Other , Tampa, Florida

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